Another 'quick project' that has taken far too long to get the final structures and collect all the data. Big thanks to Leela for pushing this till the end and eventually figuring out how the compound works! Great collaboration with Leiden University groups of Mario van der Stelt and Nathaniel Martin. For more details, go to Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria | Nature Chemistry and read the paper for free!